PENOR-DS® Injection

PENOR-DS® Injection

Procaine & Benzathine Penicillin G with Dihydrostreptomycin Injection

Composition

Each ml contains:
Procaine Penicillin G ............................. 100,000 IU
Benzathine Penicillin G ......................... 100,000 IU
Dihydrostreptomycin sulfate ............... 200 mg
Excipients .................................................. q.s. to 1 ml

Pharmaceutical Form

Sterile injectable suspension for veterinary use.

Therapeutic Class

Long-acting combination antibacterial
(Penicillins + Aminoglycoside)

Indications

PENOR-DS® Injection is indicated for the treatment of bacterial infections caused by penicillin- and streptomycin-sensitive organisms, including:

• Respiratory tract infections

• Mastitis

• Metritis

• Foot rot

• Enteritis

• Septicemia

• Skin and soft tissue infections

• Wound and post-operative infections

Target Species

• Cattle

• Sheep

• Goats

• Camels

• Horses (according to veterinary judgment)

Mechanism of Action

• Procaine Penicillin G provides immediate antibacterial action.

• Benzathine Penicillin G offers prolonged release for sustained activity.

• Dihydrostreptomycin inhibits bacterial protein synthesis, extending coverage against Gram-negative organisms.

The combination ensures rapid onset + long-acting broad-spectrum antibacterial protection.

Dosage & Administration

For intramuscular (IM) injection only.

• General dosage:
  1 ml per 20–25 kg body weight

• Frequency:
  Single dose or once daily for 2–3 days, depending on severity.

📌 Shake well before use.

Contraindications

• Hypersensitivity to penicillins or aminoglycosides

• Renal impairment

• Do not administer intravenously

• Do not use in animals with known β-lactam allergy

Side Effects

• Local injection site reactions

• Rare allergic reactions

• Nephrotoxicity with excessive or prolonged use

Withdrawal Period

(Indicative – subject to local regulations)

• Meat:
  Cattle, sheep & goats: 14–21 days

• Milk:
  5–7 days

Special Warnings

• Avoid prolonged use

• Observe antimicrobial stewardship principles

• Do not use concurrently with other nephrotoxic drugs

Storage Conditions

• Store below 25°C

• Protect from light

• Do not freeze

• Keep out of reach of children

Shelf Life

• 24 months from date of manufacture

• Use within 28 days after first opening

Presentation

• 50 ml vial

• 100 ml vial

• 250 ml multidose vial