COLISPEC-NOR® Oral Solution

COLISPEC-NOR® Oral Solution

Colistin & Spectinomycin Oral Antibacterial Solution

Composition

Each ml contains:
Colistin sulfate ........................................ 200,000 IU
Spectinomycin
(as dihydrochloride pentahydrate) ........ 50 mg
Excipients ..................................................... q.s. to 1 ml

Pharmaceutical Form

Oral solution for veterinary use.

Therapeutic Class

Broad-spectrum antibacterial combination
(Polymyxin + Aminocyclitol antibiotic)

Indications

COLISPEC-NOR® Oral Solution is indicated for the treatment of bacterial infections caused by colistin- and spectinomycin-sensitive microorganisms, including:

• Colibacillosis (E. coli)

• Salmonellosis

• Enteritis and bacterial diarrhea

• Chronic respiratory disease (CRD)

• Pasteurellosis

• Mixed Gram-negative infections

Target Species

• Poultry (broilers, breeders)

• Calves

• Lambs & kids

Mechanism of Action

• Colistin disrupts the cell membrane of Gram-negative bacteria, causing rapid bacterial death.

• Spectinomycin inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.

The combination provides synergistic, fast-acting antibacterial activity, particularly in enteric and respiratory infections.

Dosage & Administration

For oral administration via drinking water or direct oral dosing.

Poultry

• 1 ml per 1–2 liters of drinking water
  for 3–5 consecutive days

Calves, Sheep & Goats

• 1 ml per 10–15 kg body weight
  Once daily for 3–5 days

📌 Ensure medicated water is the only source of drinking water during treatment.
📌 Shake well before use.

Contraindications

• Hypersensitivity to colistin or spectinomycin

• Do not use in animals with severe renal impairment

• Avoid prolonged continuous use

Side Effects

• Generally well tolerated

• Rare digestive disturbances

• Overdose may increase risk of nephrotoxicity (colistin-related)

Withdrawal Period

(Indicative – subject to local regulations)

• Meat:
  Poultry & ruminants: 3–7 days

• Eggs:
  According to local regulatory approval

Special Warnings

• Use only when bacterial infection is confirmed or strongly suspected

• Avoid misuse to reduce antimicrobial resistance

• Observe antimicrobial stewardship principles

Storage Conditions

• Store below 25°C

• Protect from direct sunlight

• Do not freeze

• Keep out of reach of children

Shelf Life

• 24 months from date of manufacture

• Use within 28 days after first opening

Presentation

• 100 ml bottle

• 250 ml bottle

• 500 ml bottle

• 1 Liter bottle