BUTANOR® 20 Injection

BUTANOR® 20 Injection

Phenylbutazone 20% Injection

Composition

Each ml contains:
Phenylbutazone ........................................ 200 mg
Excipients ................................................ q.s. to 1 ml

Pharmaceutical Form

Sterile injectable solution for veterinary use.

Therapeutic Class

Non-steroidal anti-inflammatory drug (NSAID).

Indications

BUTANOR® 20 Injection is indicated for the treatment of inflammation, pain, and fever associated with:

• Musculoskeletal disorders

• Lameness

• Arthritis and joint inflammation

• Soft tissue injuries

• Post-operative pain

• Inflammatory conditions in horses

Target Species

• Horses

• Cattle (according to veterinary judgment)

⚠️ Primarily indicated for horses.

Mechanism of Action

Phenylbutazone inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and resulting in strong anti-inflammatory, analgesic, and antipyretic effects.

Dosage & Administration

For intravenous (IV) injection only.

Horses

• Initial dose:
  4.4 mg phenylbutazone/kg body weight
  (Equivalent to 1 ml per 45 kg body weight)

• Maintenance dose:
  2.2 mg/kg once daily if required

Cattle

• Use only under veterinary supervision.

📌 Administer slowly IV only.
📌 Do NOT administer intramuscularly.

Contraindications

• Hypersensitivity to phenylbutazone or other NSAIDs

• Gastrointestinal ulcers

• Severe renal, hepatic, or cardiac impairment

• Dehydrated animals

• Do not use concurrently with other NSAIDs or corticosteroids

Side Effects

• Gastrointestinal irritation or ulceration

• Renal toxicity with prolonged use

• Injection site irritation (if improperly administered)

Withdrawal Period

(Indicative – subject to local regulations)

• Meat:
  Cattle: 7–10 days

• Milk:
  Not approved for use in lactating animals producing milk for human consumption

⚠️ Not permitted in horses intended for human consumption in many countries.

Special Warnings

• Strictly adhere to recommended dosage

• Ensure adequate hydration

• Use only under veterinary supervision

• Observe anti-doping regulations in performance horses

Storage Conditions

• Store below 25°C

• Protect from light

• Do not freeze

• Keep out of reach of children

Shelf Life

• 24 months from date of manufacture

• Use immediately after first opening

Presentation

• 50 ml vial

• 100 ml vial

• 250 ml multidose vial